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In an embodiment, the substituted tetracycline compound is a substituted tetracycline (eg, generally, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl, R 5 is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); substituted doxycycline (eg, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); substituted minocycline (eg, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms and R 7 is dimethylamino) or substituted sancycline (wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms)?

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